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Physics of Protein Function and Evolution: From Sequence-Structure to Sequence-Ensemble Relationships

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Date and time Nov 30, 2017
from 04:10 PM to 05:00 PM
Location 60 St. George Street, MP 102
Host Claudiu Gradinaru

Hue Sun Chan

Departments of Biochemistry and Molecular Genetics, UofT

ChanHow might new protein folds evolve without detrimental effects on the biological function performed by the existing native folded  structure? Because a protein's conformational ensemble encompasses all possible conformations---not only the native fold, selection of "latent", "promiscuous" traits encoded by nonnative conformations  while the original function is largely preserved can be an efficient  route to new function. The "adaptive conflict" between the old fold and the new fold can then be resolved by gene duplication. It should  be noted, however, that not all proteins function as folded structures.

Intrinsically disordered proteins (IDPs) also perform critical functions. Remarkably, some IDPs function collectively by undergoing  liquid-liquid phase separation in and around living cells. The resulting  high-IDP phases create their own IDP-rich compartments, such as the nucleolus, to provide specific stimuli for critical biological functions. To gain physical insights into these fascinating phenomena,  I will discuss our recent efforts in using simple computational models and analytical theory to elucidate how new protein folds might have arisen in evolution and how biologically functional IDP phase separation  is governed by their genetically-coded amino acid sequences.

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