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PHY2707 F specializedCellular and Molecular Biophysics I

Course Title PHY2707 F specialized
Session fall
Year of Study 1st year
Time and Location Lectures: Thursday 1:30pm – 3:30pm MP505
Office hours: Thursday, 3:30pm-4:30pm, MP313

Andreas  Hilfinger
MP516C
905-569-4582

Homepage

Joshua  Milstein
SB4053
905-569-4598

Homepage

Official Description

This course investigates the physical properties of biomolecules with emphasis on principles of equilibrium and non-equilibrium thermodynamics and statistical mechanics that can be used to describe quantitatively biological structure and function. Through rigorously introduced new concepts and theories, and an extensive use of examples from literature, students will gain an understanding of the general importance and broad applicability of Physical Laws to life sciences. Student participation includes reading and preparing papers assigned for discussion in each lecture.

 

Specific topics will vary and may include:

 

  • Molecular associations: statistical mechanics of associations, ligand binding, allosteric interactions; MWC, KNF and SK models; hemoglobin, GPCRs, allosteric enzymes [CG]

  • Fundamental rate processes: exponential relaxations, activation energy, Kramers’ theory  for barrier crossing, single-molecule kinetics [CG]

  • Association kinetics: diffusion limit, ligand-binding to proteins, DNA and membrane receptors, reduction of dimensionality [CG]

  • Multi-state kinetics: 3-state model, separation of time-scales, pathway counting, multi-subunit kinetics [AH]

  • Random walks: diffusion, “stretched kinetics”, detailed balance, fluctuation-dissipation theorem [AH]

  • Fluctuations in biology: breaking of thermodynamic equilibrium, linear noise approximation, models of gene expression noise, fundamental limits on stochastic control [AH]

Prerequisite: There are no particular prerequisites other than basic undergraduate physics, chemistry and mathematics courses.
Co-requisite: n.a.
Exclusion: n.a.
Recommended preparation: n.a.
  BR=5 DR=SCI
Textbook "Molecular and Cellular Biophysics" by Meyer Jackson

Additional Notes

Grading scheme:
Class participation: 10% (Students are required to read assigned papers to be discussed in lectures. Submitting a critical 1-page discussion of the respective paper will be required 24h before each class.)
Assignments: 30% (Three equally weighted homework assignments.)
Research Paper Report & Presentation: 20%
Final Exam: 40%