I present the motivation for experiments which attampt to generate,and verify the existence of,quantum superpositions of two or more states which are by some reasonable criterion "macroscopically" distinct,and show that various a priori objections to this program made in the literature are flawed.I review the extent to which such experiments currently exist in the areas of free-space molecular diffraction,magnetic biomolecules, quantum optics and Josephson devices,and sketch possible future lines of development of the program.