Later this month, the Large Hadron Collider (LHC) will begin its second three-year run. The successful first run culminated in the discovery of the Higgs Boson, the final ingredient of the Standard Model.   The higher energy and intensity available in the next run will open a new window for discovery.  This talk will review what we learned in the first LHC runand describe the strategies for finding new physics in next run.  Emphasis will be placed on potential discoveries that would fundamentally change our view of the Universe: What is the source of Dark Matter?  Why is gravity so weak?  Are there extra space-time dimensions?