The Amazon rainforest, one of the planet's most biodiverse biomes, plays a crucial role in regulating global climate and the hydrological cycle of South America. However, climate change and the intensification of human activities, such as deforestation and fires, have had significant impacts on the region's ecological stability. This article analyzes the effects of land-use changes on the Amazonian climate, emphasizing the relationship between forest degradation, greenhouse gas (GHG) emissions, and changes in precipitation patterns. The impacts of atmospheric pollution, including aerosols of local and transcontinental origin, which affect the radiative balance and rainfall formation, are also discussed. Given this scenario, the need for rigorous environmental policies and international cooperation to mitigate the effects of climate change and preserve the biome's resilience is reinforced. The COP 2025 conference in Belém, Pará, is highlighted as a strategic opportunity to strengthen global commitments to forest conservation and mitigating environmental impacts.