CO2 observations from space have been applied to quantify emissions at the scale of a single facility or urban area, or the carbon balance at broader scales such as a province, country or continent. Improved emission information at all of these scales is valuable for developing and evaluating policies aimed at achieving emission reductions. This presentation will describe research progress and methods for using CO2 observations from NASA’s Orbiting Carbon Observatory 2 and 3 (OCO-2 and OCO-3) to quantify facility-scale CO2 emissions, the limitations of existing satellites, new and future mission capabilities, and the needs/requirements for operational CO2 emission monitoring from space to support climate policy.