Atom interferometers exploit spatially delocalized quantum states to make a wide variety of highly precise measurements.  Recent technological advances have opened a path for atom interferometers to contribute to multiple areas at the forefront of modern physics, including searches for wave-like dark matter, gravitational wave detection, and fundamental quantum science.  In this seminar, I will describe MAGIS-100, a 100-meter-tall atom interferometer being built at Fermilab to pursue these directions.  MAGIS-100 will serve as a prototype gravitational wave detector in a new frequency range, between the peak sensitive ties of LIGO and LISA, that is promising for pursuing cosmological signals from the early universe and for studying a broad range of astrophysical sources.  In addition, MAGIS-100 will search for wave-like dark matter, probe quantum mechanics in a new regime in which massive particles are delocalized over macroscopic scales in distance and time, and act as a testbed for advanced quantum sensing techniques.  Finally, I will discuss the potential and motivation for follow-on atomic detectors with even longer baselines.