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BiophysTO Lunchtime Talks

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May 1, 2020
Chemical Biophysics Symposium
The Chemical Biophysics Symposium (CBP) is a student-organized conference, which provides an informal venue for discussions on some of the most intriguing topics at the interface of chemistry, biology, and physics.
April 6, 2017
March 23, 2017
March 9, 2017
Probing the biophysical regulation of the de novo tumor microenvironment
Feb. 9, 2017
Single-cell modeling of the dysfunctional signaling in Chronic Lymphocytic Leukemia
Novel methods in biological physics are becoming critical in clinical application, to functionally interpret cancer genomic alterations. For Chronic Lymphocytic Leukemia (CLL), a heterogeneous disease of B-lymphocytes maturing under constitutive B-cell receptor (BCR) stimulation, the functional role of diverse clonal mutations remains largely unknown. We present here a combination of single-cell measurements and computational modeling to demonstrate that alterations in BCR signaling dynamics underlie the progression of B-cells toward malignancy. We apply nonlinear dynamics methods to reveal emergent dynamic features, namely bimodality, hypersensitivity, and hysteresis, in the BCR signaling pathway of primary CLL B-cells. We demonstrate that such signaling abnormalities in CLL quantitatively derive from BCR clustering and constitutive signaling with positive feedback reinforcement, as demonstrated through single-cell analysis of signaling motifs, computational modeling, and superresolution imaging. Such dysregulated signaling segregates CLL patients by disease severity and clinical presentation. Our findings provide a novel quantitative framework and illustrate how approaches borrowed from biological physics help assess complex and heterogeneous cancer pathology.
Feb. 23, 2017
How Bacterial Toxins Deliver Proteins Across Membranes and into Cells
Protein translocases, found in all kingdoms of life, facilitate the transport of proteins across biological membranes. How these membrane-embedded translocases recognize and transport their heterogeneous and structurally unwieldy protein substrates across membranes is poorly understood.
Jan. 26, 2017
Jan. 12, 2017
Dec. 8, 2016
Dec. 1, 2016
Physics of Tissue Morphogenesis: from cellular forces to tissue shape
Nov. 17, 2016
Studies on structure, function and interactions of the heat shock protein Hsp40
Nov. 3, 2016
How bacterial gene silencing proteins contribute to the evolution of pathogens
Oct. 20, 2016
Oct. 6, 2016
Protein-lipid complexes in the lysosome
Sept. 22, 2016
Sept. 8, 2016
Reprogramming membrane protein function by design
April 21, 2016
The design and application of genetically encoded Apollo-NADP+ sensors to image cellular metabolism in tissues
April 7, 2016
Chromatin Remodeling Machines
March 24, 2016
How viruses cross the gate much traveled: Transport of viruses into the cell nucleus
March 10, 2016
Order from disorder - defining structure in disordered proteins
In contrast to globular proteins, intrinsically disordered proteins do not form stable, compact structures under physiological conditions. Rather, often their functions are derived from their properties as extended, flexible polymers.
Feb. 25, 2016
How Does an Enzyme Unknot DNA? Statistical Mechanics of Disentangling by Topoisomerases
Feb. 11, 2016
New Initiatives in Combinatorial Microscopies: From Single Molecules to Developmental Events
Jan. 28, 2016
The Active Ear
The ear is a remarkable detector: It is both highly sensitive and selective, and operates over a large dynamic range spanning more than 12 orders of magnitude. Not only does it respond to sound, but emits it as well. These sounds, known as otoacoustic emissions (OAEs), provide a means to probe the fundamental biophysics underlying transduction and amplification in the ear. This talk will describe the empirical nature of OAE data, as well as theoretical approaches describing the underlying biomechanics using coupled oscillators. While this modeling focuses on the auditory system, an underlying goal is to identify emergent behavior (e.g., phase coherence) that arises universally in qualitatively similar complex biological systems (e.g., neural networks).
Dec. 3, 2015
Collective Cell Migration: Junctional and cytoskeletal dynamics at the interface
Dec. 17, 2015
Formation of an amyloid state by a bacterial protein: structure and consequences
Jan. 14, 2016
Hearing the shape of life: mathematical explorations of cell biology.
Hidden inside of a single individual living cell there exists a dynamical system of multiple, interrelated, chemical processes. Collectively, it is these dynamics and chemical interrelations that define life.
Nov. 19, 2015
To Cluster or Not to Cluster: New insight into the the segregation mechanism of high-copy bacterial plasmids
Nov. 5, 2015
Integrins form an expanding diffusion barrier that enables Src-family kinase activation during phagocytosis
Oct. 15, 2015
Stochastic models for the evolution of quantitative molecular traits
Oct. 1, 2015
The Biophysics of GPCR Signalling - Mapping the conformational landscape by NMR
Sept. 17, 2015
Expanding the biochemical network with full scan metabolomics
April 21, 2015
The Physics of Chromosomes: Loops and Entropy, that's what it's all about
Event series  BiophysTO Lunchtime Talks