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Research in Biological Physics

Intracellular Dynamics, Transport and Signaling

Intracellular Dynamics, Transport and Signaling

We are developing single-molecule techniques to probe chromosome organization and gene expression (Milstein), studying the dynamics of cell receptor aggregates in cellular signalling and the immune system (Gradinaru, Zilman), and modelling the transport by the Nuclear Pore Complex and other molecular "biomachines" (Zilman).

Gradinaru, Milstein, Zilman

Nonlinear Spectroscopy and Medical Imaging

Nonlinear Spectroscopy and Medical Imaging

Our research includes novel medical imaging for cancer diagnostics with nonlinear and entangled light microscopy and endoscopy (Barzda), the development and application of intense and ultra-fast laser sources (Majoribanks), and femtosecond electron spectroscopy and mass spectroscopy (Miller).

Barzda, Majoribanks, Miller

Systems and Populations

Systems and Populations

We use quantitative models and experiments to study co-evolutionary dynamics (Goyal), understand the motor and behavioral responses of C. elegans (Ryu), explore the stochastic  dynamics of the immune system (Zilman, Goyal) and genetic networks (Hilfinger), and develop a synthetic approach to biology that seeks to engineer the biological world (McMillen).

Goyal, Hilfinger, McMillen, Ryu, Zilman

Intrinsically Disordered Proteins (IDPs)

Intrinsically Disordered Proteins (IDPs)

We develop atomistic models of the structure and dynamics of intrinsically disordered proteins (Rauscher), apply single-molecule florescence techniques to study IDPs (Gradinaru), and develop coarse-grained mathematical models of IDP function (Zilman).

Gradinaru, Rauscher, Zilman