Intracellular Dynamics, Transport and Signaling
We are developing single-molecule techniques to probe chromosome organization and gene expression (Milstein), studying the dynamics of cell receptor aggregates in cellular signalling and the immune system (Gradinaru, Zilman), and modelling the transport by the Nuclear Pore Complex and other molecular "biomachines" (Zilman).
Nonlinear Spectroscopy and Medical Imaging
Our research includes novel medical imaging for cancer diagnostics with nonlinear and entangled light microscopy and endoscopy (Barzda), the development and application of intense and ultra-fast laser sources (Majoribanks), and femtosecond electron spectroscopy and mass spectroscopy (Miller).
Systems and Populations
We use quantitative models and experiments to study co-evolutionary dynamics (Goyal), understand the motor and behavioral responses of C. elegans (Ryu), explore the stochastic dynamics of the immune system (Zilman, Goyal) and genetic networks (Hilfinger), and develop a synthetic approach to biology that seeks to engineer the biological world (McMillen).
Intrinsically Disordered Proteins (IDPs)
We develop atomistic models of the structure and dynamics of intrinsically disordered proteins (Rauscher), apply single-molecule florescence techniques to study IDPs (Gradinaru), and develop coarse-grained mathematical models of IDP function (Zilman).